Difference Between Amoxicillin and Penicillin

Antibiotics are produced by microbes together with micro organism and actinomycetes normally in response to a stress or as secondary metabolites. These are efficient in opposition to different species of micro organism and therefore the time period ‘antibiotics’. The invention of antibiotics has led to elevated use of the compounds as medication. Amoxicillin and Penicillin are two such antibiotics.

Amoxicillin is an antibiotic belonging to the group of penicillin. Different members of this class embody ampicilli, piperacillin and so on. All of them have related mechanism of motion. They don’t kill micro organism, however cease the microbes from multiplying. That is achieved by stopping the microbes to construct cell partitions round them. The micro organism require cell partitions for defense and rigidity. With out cell wall they can not survive and therefore die off. The antibiotic types differ within the spectrum of motion or the microbes to which they’re antagonistic. Amoxicillin is efficient in opposition to many micro organism together with H. influenzae, N. gonorrhoea, E. coli, Pneumococci, Streptococci, and sure strains of Staphylococci.

Penicillin is the primary era antibiotic having related features however differing in efficacy.


Amoxicillin is a semisynthetic aminopenicillin antibiotic structurally associated to the penicillin household. There are related structural analogs together with ampicillin which gives related operate additionally. The moderate-spectrum antibiotic is efficient in opposition to a variety of Gram-positive micro organism and a restricted variety of Gram-negative microbes.

It’s used to deal with sure bacterial infections akin to pneumonia; bronchitis; gonorrhea; and ENT infections, Urinary tract, and pores and skin infections. Helicobacter pylori, micro organism that causes ulcers is vulnerable to amoxicillin when utilized in mixture with different medication. The bacterial motion is much like that of penicillin by stopping the cell wall formation in micro organism.

The antibiotic has higher absorption charges, and is the primary alternative of ear an infection. It readily penetrates into the tissues and tissue fluids. The antibiotic can’t cross the mind and spinal fluid and therefore not efficient for mind tissues. It’s efficient and protected to be used in excessive threat class of individuals together with pregnant girls and youngsters.

The drugs is cheaper and safer as proved by greater than forty years of analysis research. Allergic reactions are frequent and the drug is extra prone to end in diarrhoea as aspect impact. It isn’t efficient in opposition to bacterial species producing beta lactamase enzyme. A current research has discovered a correlation between tooth enamel defects and elevated use of amoxicillin infancy.


Penicillin is a slender spectrum antibiotic efficient in opposition to most Gram optimistic and just a few Gram unfavorable micro organism. The mode of motion is analogous with the inhibition of cell wall formation within the microbe. The antibiotic is efficient in opposition to infections brought on by streptococcus, staphylococcus, pneumococcus and so on.

The prophylaxis is simpler and remedy might be accomplished by both oral or intravenous strategies. The antibiotic is safer and could also be taken with meals with out getting inactivated by the gastric acid. The penetration ranges are good in most tissues and come low-cost. That is thought of protected for pregnant girls and youngsters as proved from the research. Being the primary antibiotic to be found, it has undergone additional modifications to swimsuit the wants and improve the efficacy.

The antibiotic has a really low half life requiring it to be administered as soon as in six hours for optimum impact. The hypersensitivity related to Penicillin has been historic and well-known and is reported in quite a few circumstances. The style will not be so interesting to youngsters.

Difference between Amoxicillin and Penicillin

Absorption- Amoxicillin is healthier absorbed from the gastrointestinal tract in comparison with different Penicillins akin to penicillin V and ampicillin. The degrees of drug in blood are excessive and steady with administration of Amoxicillin.

Synthesis- Amoxicillin’s superior absorption could also be attributed to the semi artificial nature. Penicillin is artificial penetrates much less and therefore much less efficient.

Efficacy- Amoxicillin is simpler and acts in opposition to a variety of pathogenic microbes.

Penetration into tissues- Amoxicillin penetrates higher into tissues than penicillin. The one exceptions are mind tissues and spinal fluid.

Security- Each are appropriate to be used in being pregnant and in paediatrics.

Value- Each antibiotics are cheaper and can be found in generic formulations.

Period of treatment- Remedy with Amoxicillin requires fewer programs of antibiotics in comparison with Penicillin. These might be taken for a short time.

Motion- Each of them act on the micro organism by inhibiting cell wall formation.

Supply- Each are remoted from molds.



1. Each belong to the category of Penicillin due to the similarity in motion, construction and supply of origin.

2. They differ in effectiveness in penetration which contributes to the efficacy.

3. Each have confirmed analysis confirming the security in excessive threat class use.

4. They’re cheaper generic variations and can be found simply.

5. Hypersensitivity is a standard concern for each medication.