Difference Between Vitamin B6 and Vitamin B12

Nutritional vitamins are very important vitamins important for the conventional functioning of various enzymes and metabolic pathways of the physique. All nutritional vitamins are wanted for particular capabilities and most are obtained from meals. Nutritional vitamins could be categorised into water soluble and fats soluble sorts. B nutritional vitamins are basically water soluble nutritional vitamins with totally different subcategories primarily based on their chemical construction.

Vitamin B6 and Vitamin B12 are nutritional vitamins that are related in operate additionally to a sure extent. About 100 enzymes concerned in protein metabolism require Vitamin B6 for regular functioning. Pyridoxine, pyridoxamine and pyridoxal are the three types of vitamin B6.

Vitamin B12 can be water soluble having totally different varieties akin to Methylcobalamin and 5-deoxyadenosylcobalamin. These two varieties participate in human metabolism. Vitamin B12 requires the cofactor cobalt and therefore usually referred to as as ‘cobalamines’.

Vitamin B6

Vitamin B6 is a vital consider RBC metabolism and environment friendly functioning of immune and nervous methods. The vitamin is well out there in fortified cereals, meat, fish, poultry, fruits and greens. Tryptophan is transformed to niacin by Vitamin B6.

Vitamin B6 has a few of the main capabilities akin to sustaining your blood glucose and to provide haemoglobin. In fasting, when the caloric ranges go down, the physique synthesizes glucose from different carbohydrates utilizing Vitamin B6. Additionally it is important for environment friendly immune response and antibody manufacturing.

Vitamin B6 deficiency might trigger dermatitis, glossitis, confusion, despair and convulsions. Typically it might trigger anemic situations additionally. These signs are extra basic and therefore can’t be attributed to the deficiency of vitamn B6 alone. Additionally the signs seem at a later stage after power lack of vitamins.

The higher tolerable degree for adults have been discovered as 100 mg per day and as soon as the dosage crosses this restrict, the physique usually reveals adversarial results. An excessive amount of of the vitamin also can trigger neuropathy.

Vitamin B12

Vitamin B12 is a water soluble vitamin present in animal merchandise in certain type and is freed on motion of hydrochloric acid and gastric protease. The vitamin is required for the formation of pink blood corpuscles, DNA synthesis and operate of nervous tissue. The deficiency ends in a severe kind of anaemia referred to as pernicious anaemia which happens in elder folks. Using vitamin B12 in different situations akin to growing older, immune system functioning, reminiscence loss and so on requires additional proof to show the results. Contraindications have been famous with consumption of different nutritional vitamins, particularly vitamin C.

Pernicious anaemia if left untreated ends in an irreversible megaloblastic anaemia and issues of the nervous system. The vitamin is concerned within the formation of methyl malonyl CoA, and therefore the molecule is an efficient indicator for the extent of vitamin B12.

The flexibility of absorption of vitamin B12 from eating regimen varies in keeping with the person’s make up. Oral and sublingual dietary supplements can be found. A vegetarian meals doesn’t present enough quantities of vitamin B12 and thus may have dietary supplements. Additionally it is essential for myelin synthesis and restore.


1. Each vitamin B6 and vitamin B12 are concerned in conversion of homocysteine to methionine.

2. Vitamin B12 requires a transcobalamin molecule to move the vitamin to the tissues whereas vitamin B6 doesn’t require any particular transporter.

3. The absorption of Vitamin B12 is mediated by an intrinsic issue.

4. The meals certain vitamin B12 is certain to haptocorrin (R-protein) which requires motion of pancreatic enzymes to be cleaved and launched.

5. The consequences of deficiency are extra pronounced in vitamin B12 in comparison with vitamin B6. The first causes of deficiency of vitamin B12 contains vegan eating regimen, impaired absorption and insufficient utilization and so on

6. The standard supply of vitamin B6 is fruits and greens and a vegan eating regimen doesn’t hamper the adequacy of the vitamin within the eating regimen. Vitamin B12 ranges scale back considerably over a vegan eating regimen.

7. Dietary deficiency is uncommon with vitamin B6 though severe and power scarcity could cause illness Pellagra.

8. Each nutritional vitamins are efficient in lowering the extent of homo-cysteine in blood.

9. The deficiency of each nutritional vitamins can have an effect on the neurological capabilities.



The nutritional vitamins B6 and B12 are required for the nucleic acid metabolism, lipid metabolism and so on. Each scale back the homo cysteine ranges in blood and are supplemented by way of eating regimen. Vitamin B12 requires a steel ion of cobalt to behave as cofactor for nomal functioning.

The consequences of deficiency are extra pronounced in vitamin B12 in comparison with vitamin B6. Major deficiency is nearly a rarity in case of vitamin B6. Over dosage can happen not often. Vitamin B12 is saved in human physique whereas Vitamin B6 is excreted frequently. The perfect eating regimen ought to include a balanced consumption of each nutritional vitamins. Often medical doctors prescribe a multivitamin complement, together with folate along with nutritional vitamins B6 and B12 and it’s discovered to be efficient for a lot of the issues associated to the vitamin deficiency.